Glyceryl trinitrate is an organic nitrate with potent vasodilator activity. Intravenous nitroglycerin is among the most potent drugs to treat acute coronary syndromes, such as unstable angina and acute myocardial infarction and it is the first-line treatment for acute congestive heart failure and specifically for acute pulmonary oedema due to its venodilating effects and its effectiveness in reducing cardiac preload. It induces rapid haemodynamic effect characterized by a steep dose-response relationship, therefore prompt and safe titration to the optimum dose is achieved simply by regulating the infusion.

THERAPEUTIC AREA
Cardiovascular

PRESENTATIONS
5mg/1ml ampoules for injections, 25mg/5ml and 50mg/50ml vials for injection

INDICATIONS

Unresponsive congestive heart failure, including that secondary to acute myocardial infarction; acute left-sided heart failure and acute myocardial infarction.
Refractory unstable angina pectoris and coronary insufficiency, including Prinzmetal's angina.
Control of hypertensive episodes and/or myocardial ischaemia during and after cardiac surgery.
Induction of controlled hypotension for surgery.

DOCUMENTATION

EU CTD dossier available
CPP available